Effective treatment of substance use disorders requires precise medication selection, dosing, and monitoring across diverse clinical contexts. Psychopharmacology for SUD integrates neurobiological mechanisms with practical prescribing to reduce craving, prevent relapse, and stabilize co-occurring psychiatric symptoms. This session connects receptor pharmacodynamics to real-world care pathways—covering agonists, partial agonists, antagonists, and modulators across opioid, alcohol, nicotine, stimulant, and sedative use disorders. We compare induction versus maintenance strategies, discuss cross-titration and tapering, and examine special populations such as pregnancy, older adults, and patients with hepatic or renal impairment. Safety remains paramount: we’ll address QTc risk, overdose mitigation, and interactions with antidepressants, antipsychotics, and anticonvulsants. Beyond individual prescribing, we focus on team workflows, measurement-based care, and equity: access barriers, cultural adaptation, and cost-sensitive regimens that patients can actually continue. By session end you’ll be able to connect target symptoms with mechanism, choose starting and target doses, use lab and symptom feedback to adjust care, and plan transitions across levels of care. Explore how Psychopharmacology for SUD, conversations within psychopharmacology for SUD conference, and core ideas like medication-assisted treatment shape safer, more durable recovery trajectories.