Schizophrenia spectrum conditions require phase-specific strategies that prioritize functional recovery—not just symptom scores. Schizophrenia Spectrum Disorders covers prodrome, first-episode, multi-episode, and treatment-resistant trajectories, highlighting how negative and cognitive symptoms drive disability even when positive symptoms remit. We clarify diagnosis and differentials (substance-induced psychosis, mood disorders with psychosis, neuroinflammatory and metabolic causes) and explain why duration of untreated psychosis predicts long-term outcomes. Pharmacotherapy is necessary but not sufficient: the choice of antipsychotic should reflect efficacy, side-effect profile, patient goals, and cardiovascular/metabolic risk. We detail when and how to introduce long-acting injectables, how to manage clozapine from initiation to monitoring, and how to layer psychosocial treatments—CBT-p, family work, supported employment/education, cognitive remediation—to improve participation in school, work, and relationships. Physical health is core care: screen and treat metabolic syndrome early; manage tobacco use, sleep disturbance, and sedentary behavior; coordinate with primary care. Safety planning addresses suicidality, aggression risk, and intoxication-triggered exacerbations, with clear collaboration between outpatient, emergency, and inpatient services. Measurement makes recovery visible—side-effect burden, social functioning, and goal attainment—not just PANSS totals. Equity considerations include language access, housing support, digital inclusion, and peer leadership. With an integrated plan, Schizophrenia Spectrum Disorders, practical knowledge from a schizophrenia conference, and evidence-based clozapine management can shift the arc from relapse to resilience.